1 Molecular Diagnostics Centre, University Department of Haematology, Manchester Royal Infirmary, Manchester, UK 2 National Centre for Hereditary Coagulation Disorders, St James’s Hospital, Dublin, Ir.

Correspondence: DG Gilliland, Division of Hematology, Brigham and Women’s Hospital, Children’s hospital research building, 1 Blackfan Circle, 5th Floor, Boston, MA 02115, USA. E-mail: [email protected]

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